Br J Ophthalmol 74(1):19–21Ĭooper CA, Bergamini MV, Leopold IH (1980) Use of flurbiprofen to inhibit corneal neovascularization. Searle AE, Pearce JL, Shaw DE (1990) Topical use of indomethacin on the day of cataract surgery. Hersh PS, Rice BA, Baer JC, Wells PA, Lynch SE, McGuigan LJ et al (1990) Topical nonsteroidal agents and corneal wound healing. Radi ZA, Render JA (2008) The pathophysiologic role of cyclooxygenases in the eye. Therefore, the oil eye drops may be a promising alternative, to aqueous eye drops circumventing poor retention in management of ocular ailments.Ībelson MB, Butrus SI, Kliman GH, Larson DL, Corey EJ, Smith LM (1987) Topical arachidonic acid: a model for screening anti-inflammatory agents. Further, results of gamma scintigraphy also indicated prolonged retention. The in vivo efficacy of optimized castor oil formulation was found to be better than control as well as CXB-aqueous suspensions in arachidonic acid triggered eye swelling model in rabbits. Incorporation of benzyl alcohol resulted in a significant increase in drug permeation across the cornea ( p < 0.05).
Partition behavior, trans-corneal permeation, viscosity, in vivo anti-inflammatory study and gamma scintigraphy of the preparations were investigated. The aim of the present work was to formulate oil preparations of celecoxib in different oils. However, the aqueous drops suffer a major setback due to the rapid drainage leading to loss of drug. The most comfortable approach to deliver an active pharmaceutical ingredient to the eye has been via topical instillation of aqueous drops.
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